Cox proportional hazards habits were used so you can estimate RRs and 95% CIs

RRs (95% CI) regarding full, ischemic, and you will hemorrhagic shots from the quintiles away from joint diet score for magnesium, potassium, and you can calcium supplements consumption when you look at the 86,149 ladies in the new NHS I and you can 94,715 ladies in the fresh NHS II 1

We current the fresh meta-analyses away from possible training of slimming down magnesium ( 21), potassium ( 22), and you may calcium supplements ( 23) intakes and you will chance of coronary arrest

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

RRs (95% CI) of overall, ischemic, and you may hemorrhagic shots from the quintiles off combined eating plan ratings to have magnesium, potassium, and you may calcium supplements intakes inside 86,149 women in the fresh new NHS I and you may 94,715 women in the brand new NHS II 1

We updated this new meta-analyses out-of potential degree from weightloss magnesium ( 21), potassium ( 22), and you will calcium supplements ( 23) intakes and risk of heart attack

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.

We looked at overall and weightloss intakes each and every mineral and you can Little People free and single dating site chance out of coronary arrest to decide any potential nonlinear association by using restricted cubic splines; yet not, zero extreme deviation of linearity was observed. On the other hand, we looked the potential feeling amendment from the ages, blood pressure, or diabetic issues toward family between overall intake of all the 3 nutritional elements and you can likelihood of total coronary attack. Zero significant effect amendment are noticed because of the these types of issues.

Early in the day meta-analyses incorporated is a result of earlier in the day analyses on NHS ( 10); these types of abilities was indeed replaced because of the contributes to the current data. While doing so, the newest literature is appeared, and you may latest possible studies ( 8, 24) had been found in such current meta-analyses. Zero ranging from-studies heterogeneity are seen when it comes to of your own step three nutritional elements. The brand new joint RR of overall coronary attack is 0.87 (95% CI: 0.83, 0.92) getting a hundred-mg/d improve from magnesium consumption, 0.91 (95% CI: 0.88, 0.94) to own a good one thousand-mg/d increase off potassium consumption, and you may 0.98 (95% CI: 0.94, 1.02) to own a 3 hundred-mg/d increase out-of calcium supplements intake.